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21.
干河煤矿+80水平三采区皮带巷上部赋存坚硬岩层,围岩压力较大;针对坚硬顶板条件,拟定以强主动支护为主的对策,即采用锚网索喷联合支护技术;应用表明,该巷道围岩变形量不大,验证了该支护技术安全可靠。  相似文献   
22.
利用计算流体力学(Computational Fluid Dynamic, CFD)方法,针对连续螺旋折流板换热器建立物理模型和数学模型,在管侧介质为水和壳侧介质为原油条件下,研究不同原油流量及螺旋角对螺旋折流板换热器内部流场、换热性能及阻力性能的影响,并拟合了水油换热时螺旋折流板换热器的Nu、f与Re的关联式。结果表明:22°螺旋角的螺旋折流板换热器与其它较小螺旋角换热器对比,壳侧压降和换热系数逐渐减小,综合换热性能最佳。通过对壳侧原油为层流状态下的阻力系数和对流换热系数关系式进行拟合,更好地指导水-油连续螺旋折流板换热器的热力设计。  相似文献   
23.
Ripe carambolas are hard to store and transport, while freeze-dried ones are easy to store. However, its long production time leads to higher costs. This study shows that high hydrostatic pressure (HHP) treatment could shorten the freeze-drying time of carambola slices. After HHP treatment (25–250 MPa), the drying time of the fresh sample can be shortened by 33.3–44.4% and the distribution of water and pigment in tissues is much uniform. With the increment of the pressure, 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radical scavenging rate are increased. At 250 MPa, the total phenolic content (TPC) increased from 11.34 to 13.36 mg GAE g−1, and the total flavonoid content (TFC) of the control sample was increased from 10.77 to 12.73 mg RE g−1. Compared with the untreated sample, HHP treatment can enhance the flavour and shorten the freeze-drying time. This work guides the application of HHP technology for drying food processing.  相似文献   
24.
Diabetes mellitus is a major cause of chronic kidney disease and end-stage renal disease. However, the management of chronic kidney disease, particularly diabetes, requires vast improvements. Recently, sodium-glucose cotransporter-2 (SGLT2) inhibitors, originally developed for the treatment of diabetes, have been shown to protect against kidney injury via glycemic control, as well as various other mechanisms, including blood pressure and hemodynamic regulation, protection from lipotoxicity, and uric acid control. As such, regulation of these mechanisms is recommended as an effective multidisciplinary approach for the treatment of diabetic patients with kidney disease. Thus, SGLT2 inhibitors are expected to become key drugs for treating diabetic kidney disease. This review summarizes the recent clinical evidence pertaining to SGLT2 inhibitors as well as the mechanisms underlying their renoprotective effects. Hence, the information contained herein will advance the current understanding regarding the pleiotropic effects of SGLT2 inhibitors, while promoting future research in the field.  相似文献   
25.
A cross-sectional study was conducted to investigate the impact of solid fuel use for heating and cooking on blood pressure (BP) and hypertension, using data from the China Health and Retirement Longitudinal Study (CHARLS). The primary fuels used for indoor heating and cooking were collected by questionnaires, respectively. Hypertension was defined based on self-report of physician's diagnosis, and/or measured BP, and/or anti-hypertensive medication use. Multivariate logistic regression models were constructed to assess the associations. Among 10 450 eligible participants, 68.2% and 57.2% used indoor solid fuel for heating and cooking, respectively. Compared with none/clean fuel users, solid fuel for heating was associated with elevated BP (adjusted β: 2.02, 95% CI: 1.04–3.01 for systolic BP; adjusted β: 1.36, 95% CI: 0.78–1.94 for diastolic BP) and increased risk of hypertension (adjusted odds ratio: 1.15, 95% CI: 1.03–1.29). The impact of indoor solid fuel for heating on BP was more evident in rural and north residents, and hypertensive patients. We did not detect any significant associations between solid fuel use for cooking and BP/hypertension. Indoor solid fuel use is prevalent in China, especially in the rural areas. Its negative impact on BP suggested that modernization of household fuel use may help to reduce the burden of hypertension in China.  相似文献   
26.
In a vehicular fuel cell system, alternative load and frequent purge action can lead to anode pressure varies with the hydrogen mass flow fluctuation. It's crucial to control the pressure difference between anode and cathode within a reasonable range to avoid adverse phenomena such as membrane failure, reactant starvation, or even water management fault. In this paper, an improved proportional integrative (PI) controller by the fuzzy logic technique that considers the engineer experience and knowledge on the hydrogen supply system behavior is proposed for hydrogen pressure control, in which the PI parameters are tuned by a fuzzy decision process. Furthermore, load current and purge action regarded as input disturbances are applied for feedforward compensation to reduce the pressure response hysteresis. A hydrogen supply subsystem based on the proportional valve is modeled, and corresponding parameters are determined by analyzing the response time and steady pressure fluctuation. The performance of the conventional PI controller, the fuzzy logic PI (FLPI) controller and fuzzy logic PI with feedforward (FLPIF) controller is validated. The presented results indicated that the FLPI controller significantly improves the dynamic response of hydrogen pressure compared to the PI controller, and the FLPIF controller can further reduce overshoot caused by disturbance. Finally, the proposed FLPIF controller is implemented on a rapid prototype platform of the hydrogen supply subsystem and an actual fuel cell system, exhibiting satisfactory performance.  相似文献   
27.
郑煤集团杨河煤业43采区樊寨副立井施工中需要穿过预计涌水量187 m3/h、厚57 m的砂岩含水层。针对第1回次采用普通水泥工作面预注浆、吸浆量少、升压快、效果差、达不到预期目的等不利情况,在后3回次采用大压力,白银水泥、超细水泥等新材料、单孔上下端正反同时注浆新工艺,采用压注清水、水玻璃,利用水玻璃的黏性,反复冲洗钻孔把细小裂隙中锈蚀颗粒带出,打开注浆通道,同时针对竖向裂隙多、横向裂隙不联系,加密钻孔布置,缩小注浆段高,取得了较好的注浆效果。  相似文献   
28.
Reactive oxygen species (ROS) plays a key role in the pathogenesis of primary open-angle glaucoma (POAG), a chronic neurodegenerative disease that damages the trabecular meshwork (TM) cells, inducing apoptosis of the retinal ganglion cells (RGC), deteriorating the optic nerve head, and leading to blindness. Aqueous humor (AH) outflow resistance and intraocular pressure (IOP) elevation contribute to disease progression. Nevertheless, despite the existence of pharmacological and surgical treatments, there is room for the development of additional treatment approaches. The following review is aimed at investigating the role of different microRNAs (miRNAs) in the expression of genes and proteins involved in the regulation of inflammatory and degenerative processes, focusing on the delicate balance of synthesis and deposition of extracellular matrix (ECM) regulated by chronic oxidative stress in POAG related tissues. The neutralizing activity of a couple of miRNAs was described, suggesting effective downregulation of pro-inflammatory and pro-fibrotic signaling pathways, including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB), transforming growth factor-beta 2 (TGF-β2), Wnt/β-Catenin, and PI3K/AKT. In addition, with regards to the elevated IOP in many POAG patients due to increased outflow resistance, Collagen type I degradation was stimulated by some miRNAs and prevented ECM deposition in TM cells. Mitochondrial dysfunction as a consequence of oxidative stress was suppressed following exposure to different miRNAs. In contrast, increased oxidative damage by inhibiting the mTOR signaling pathway was described as part of the action of selected miRNAs. Summarizing, specific miRNAs may be promising therapeutic targets for lowering or preventing oxidative stress injury in POAG patients.  相似文献   
29.
30.
西湖凹陷中部西斜坡地区超压成因机制   总被引:10,自引:5,他引:5  
侯志强  张书平  李军  赵靖舟  刘云  田连辉  仲晓  陈梦娜  徐泽阳 《石油学报》2019,40(9):1059-1068,1124
沉积盆地超压成因研究已取得了重要进展,关于超压主要成因的认识也发生了重要变化,以往一些被普遍认为属于典型不均衡压实成因的超压已被部分或完全否定,生烃作用作为超压成因的普遍性得到愈来愈多的证实。西湖凹陷多个构造带的不同层位均发育超压,目前认为超压的形成仍然离不开不均衡压实(欠压实作用)的贡献。根据异常压力形成的基本地质条件和异常压力产生的地质、地球物理效应两方面因素,利用测井曲线组合分析法、鲍尔斯法(加载-卸载曲线法)、声波速度-密度交会图法、孔隙度对比法、压力计算反推法以及综合分析法系统解剖分析了西湖凹陷中部西斜坡地区平湖组不同岩性异常压力成因。研究结果表明:西湖凹陷中部西斜坡泥岩中烃源岩超压主要为自源生烃增压,非烃源岩超压为邻源压力传导成因。储层中至少存在常压-超压型和常压-超压-常压型两种压力结构类型,异常压力自南向北顶界面逐渐变深,主要为油气在生烃增压驱动下向储层运移过程中的压力传导所致。  相似文献   
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